RETN Gene Single Nucleotide Polymorphism Profile on Triglyceride-Glucose Index as Insulin Resistance Proxy Among Cohort Population of Non-Communicable Diseases in Bogor

Genetic factors such as single nucleotide polymorphisms (SNPs) are thought to contribute the increasing incidence of diabetes mellitus (DM) through insulin resistance. SNPs in RETN (resistin) gene encoding resistin protein have been reported play a role causing abnormalities blood glucose and lipid metabolism. Still, studies related this rarely explored cohort population models. This study aimed evaluate relationship trend triglyceride-glucose index (TyG) proxy for The data were obtained from results biomedical laboratory examination among participants Kebon Kalapa subdistrict, Bogor, every odd year period between 2015-2021 genotyping (rs3745367). generalized linear model (GLM) repeated measurement technique was used with TyG value dependent variable. GLM analysis showed that although there significant difference observation periods [F(2,87, 1671,1)=41,10, p-value <0.001], that’s not case SNP [F(5,73, 1671,1) = 1.09, 0.367]. However, multivariate test suggested association these age DM status [F(4, 583)=2.48, 0.043]. In conclusion, may require interaction other or genes induce resistance act by indirect glucose–fatty acid metabolic cycle mechanisms.